LOS ANGELES (AP) -- Caleb Williams passed for 281 yards and three touchdowns and ran for another score while playing only the first half, Zachariah Branch returned a punt 75 yards for a TD, and No. 6 Southern California beat Stanford 56-10 Saturday night in this decades-old rivalry's final chapter for the foreseeable future.
MarShawn Lloyd and Austin Jones also rushed for scores, and Dorian Singer, Brenden Rice and Lake McRee caught TD passes while their Heisman Trophy winner led USC (3-0, 1-0 Pac-12) to one of the most prolific first halves in school history.
The Trojans racked up 433 yards of offense and got seven touchdowns by seven players while building a 49-3 halftime lead - the third-largest in Pac-12 history - in the conference's final opening game, at least in its current configuration.
USC is headed to the Big Ten and Stanford will join the ACC next year after the collapse of the conference they've called home in various forms since 1922. This was also the last scheduled meeting between USC and its oldest rival in a series that began in 1905, although the private schools could resume it in the future.
Ashton Daniels got hurt while getting sacked early in the second quarter of his second career start for Stanford. Backup Justin Lamson passed for 121 yards and rushed for the Cardinal's only touchdown with 3:35 to play.